Nucleome Informatics: Unraveling the Genomes for a Better Future

Nucleome Informatics

Nucleome Informatics is well regarded in the Life sciences industry for its expertise in de novo genome sequencing of larger genomes using hybrid assembly approach. Pharma companies and hospitals have been using Nucleome’s genome resequencing, exome sequencing and targeted resequencing services quite often. Nucleome plays a major role by providing Genomics and Bioinformatics analysis support for scientists working in the field of genomes, transcriptomes, metagenomes, and epigenomes research. Nucleome’s flagship product includes software DrSeq for RNA sequence analysis software, DrSeq Genome Survey and Big Data Decoder server specially designed for NGS analysis. Nucleome also has pipelines for Exome, Metagenome, transcriptome and amplicon datasets developed in-house. It has a variety of projects involving discovery of SNP markers by resequencing of human samples and identifying the complete Genetic makeup of the following organisms like, Buffalo, Pomegranate, Mango, Pigeon Pea, Mosquito, Dhole, Rice varieties, Indian Bengal Tiger, Great Indian Bustard, Eggplant Borer, etc.
Distinguished Services
Nucleome has successfully completed many significant plants, animals and microbial de novo genomes and has been regularly working on sequencing of cancer genomes and human exomes. Wildlife and plant genome sequencing and populations genomics is another area of interest where it provides NGS services regularly. The last six years have seen the company assemble 18 plants, 9 animals, 5 insects, and over 100 microbial genomes and analyzed human genome and exome sequencing data (4580 samples by Jan 2019). It was also involved in prestigious sequencing projects like Mango, Pomegranate, Tiger, Indian Wild Dog, Leopard and Insect genome sequencing programs. It also offers cfDNA Sequencing and Cell line genome sequencing services.
The Insightful Minds
The company is a resultant of three genius minds coming together.
Dushyant Singh Baghel, Founder, MD and CEO hold an MS in Biotechnology from Bharathiar University and executive education in management from Indian School of Business, Hyderabad. He carries twelve years of experience in sequencing and assembly of genomes. A self-motivated person with true qualities of entrepreneurship and leadership, he started the company in the year 2012 with his partners and Co-Founders Abhishek Tripathi and Bipin Kumar.
Abhishek Tripathi, VP – R&D and Operations with an MS in Biotechnology has an experience of twelve years in Genomics Industry.
Bipin Kumar, VP – Corporate Sales with an MS in Biotechnology has an experience of thirteen years in Genomics and diagnostics Industry.
With a good understanding of Genomics market in India and their experience, they laid the foundation for Nucleome. Under the leadership of the founders Dushyant Singh Baghel, Bipin Kumar and Abhishek Tripathi, the team has designed and developed software for data analysis, assembled various genomes, completed more than 500 Genome and Transcriptome projects in a span of 6 years. Currently Nucleome is being considered as India’s fastest growing genomics and bioinformatics solution provider.
Hard Work is all it takes to Succeed
Nucleome has invested its entire seed funding in building a well-equipped laboratory with sophisticated wet lab instruments and servers like BigData Decoder which are specially designed for next generation sequencing data analysis along with NGS analysis pipelines on online cloud servers like Google genomics, Amazon Web Server and DNA nexus.
It has successfully completed various projects in association with various International organizations like CNRGV (France), Fasteris SA (Switzerland), Koppert Biological Systems (The Netherlands), Cold Spring Harbor Laboratory (USA), McDonnell Genome Institute, (USA), University of California (USA), Yale University (USA), New York Genome Center (USA), Washington University(USA), The Queensland Alliance for Agriculture and Food Innovation(Australia) and Indian institutes like CCMB, CIBA, IHBT, NRCP, NRCPB, ILS and NDDB. Nucleome has also built a sound association with all the major institutes under ICAR, CSIR, DBT and various hospitals including Tata Memorial Hospital Mumbai and private organisations like ITC and Beej Sheetal Seeds.
Nucleome was awarded India’s 20 Most Promising Pharma & Life Science Technology Solution Provider Companies 2016′ by a leading magazine.
Using Nucleome’s services researchers have published several Research Papers.
Paper in the field of Animal Genomics:

  • The Cuon Enigma: Genome survey and comparative genomics of the endangered Dhole 1 (Cuon alpinus) in bioRxiv
  • High coverage genome sequencing and identification of genomic variants in Bengal tiger (Panthera tigris tigris) in bioRxiv
  • Genome Plasticity in Cultured Leishmania donovani: Comparison of Early and Late Passages in Frontiers in Microbiology
  • RNA-Seq Revealed Expression of Many Novel Genes Associated With Leishmania do no vani Persistence and clearance in the Host Macrophage in Frontiers in Cellular and Infection Microbiology

Papers in the field of Agri Genomics:

  • Analysis of DNA methylome and transcriptome profiling following Gibberellin A3 (GA3) foliar application in Nicotiana tabacum L. in Indian Journal of Plant Physiology
  • Identification of candidate pathogenicity determinants of Rhizoctonia solani AG1-IA, which causes sheath blight disease in rice in Current Genetics of Springer Nature
  • Alterations in rice chloroplast integrity, photosynthesis and metabolome associated with pathogenesis of Rhizoctonia solani in Scientific Reports
  • Sequencing, Denovo Assembly, Functional Annotation and Analysis of Phyllanthus amarus Leaf Transcriptome Using the Illumina Platform in Frontiers in Plant Science
  • Analysis of high iron rice lines reveals new miRNAs that target iron transporters in roots in Journal of Experimental Botany

Lapping up the Opportunities
The Pharma and life science industry is bustling with ideas and applications. The increasing application of genomics in biotech and pharmaceutical research and development has created a huge commercial market for sequencing and bioinformatics worldwide. The explosive growth of biological techniques necessitates the acquisition, processing, analysis, and integration of the data. These immense amounts of data are generated by the experiments as diverse as genomics, cloning, expression analysis, genotyping, cellular analysis and others. Many young entrepreneurs are looking at it as an opportunity for new startups. The founders advise them saying “Dare to dream…..Follow your dream….Live your dream…..Strive hard to achieve your dream.”
For a Better Future
Nucleome aims at a healthier future through revolutionary genetic analysis solutions. It is committed to generating rapid, appropriate and high-quality results which can create a great difference in research projects.
Nucleome’s focus has always been in the field of Plant, Animal and Human Genomics and is planning to strengthen its position in this field. It has planned to raise its SeriesA funding to expand its infrastructure by building India’s largest genomics and supercomputing bioinformatics facility. It aims to fund and propel its Population genomics program to sequence 10,000 human genomes and 100,000 exomes of various cancer and diabetics patients in India.

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